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M9470004.TXT
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1994-07-02
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Document 0004
DOCN M9470004
TI Induction of apoptosis in a T lymphoblastoid cell line infected with
feline immunodeficiency virus.
DT 9409
AU Ohno K; Okamoto Y; Miyazawa T; Mikami T; Watari T; Goitsuka R; Tsujimoto
H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of;
Agriculture, University of Tokyo, Japan.
SO Arch Virol. 1994;135(1-2):153-8. Unique Identifier : AIDSLINE
MED/94256834
AB The mechanism of cell death induced by feline immunodeficiency virus
(FIV) infection was investigated in an interleukin 2(IL-2)-dependent
T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected
MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the
cytopathic effect (CPE) observed in these cells was due to apoptosis.
Infection of MYA-1 cells with FIV was associated with suppression of the
proliferative response of the cells to exogenous IL-2 prior to DNA
fragmentation. These findings suggest that FIV-induced CPE in these
T-lymphoblastoid cells is associated with apoptosis possibly due to a
defect in the IL-2 signal transduction pathway.
DE Animal *Apoptosis Cats Cell Division/DRUG EFFECTS Cell Line DNA
Damage Flow Cytometry Human Immunodeficiency Virus,
Feline/*PHYSIOLOGY/PATHOGENICITY Interleukin-2/PHARMACOLOGY Receptors,
Interleukin-2/*BIOSYNTHESIS Recombinant Proteins/PHARMACOLOGY
T-Lymphocytes/*CYTOLOGY/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).